Reaction Details |
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Target | Amiloride-sensitive sodium channel subunit alpha |
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Ligand | BDBM50190495 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_375179 (CHEMBL868533) |
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IC50 | 77±n/a nM |
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Citation | Hirsh, AJ; Molino, BF; Zhang, J; Astakhova, N; Geiss, WB; Sargent, BJ; Swenson, BD; Usyatinsky, A; Wyle, MJ; Boucher, RC; Smith, RT; Zamurs, A; Johnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem49:4098-115 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Amiloride-sensitive sodium channel subunit alpha |
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Name: | Amiloride-sensitive sodium channel subunit alpha |
Synonyms: | Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 75711.44 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_375179 |
Residue: | 669 |
Sequence: | MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
SSTCPLGGP
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BDBM50190495 |
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n/a |
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Name | BDBM50190495 |
Synonyms: | CHEMBL209104 | N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[5-(4-methoxyphenyl)pentyl]-guanidine |
Type | Small organic molecule |
Emp. Form. | C18H24ClN7O2 |
Mol. Mass. | 405.882 |
SMILES | COc1ccc(CCCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:11.10| |
Structure |
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