| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50607576 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2262969 (CHEMBL5217980) |
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| Ki | 2500±n/a nM |
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| Citation |  Bröker, J; Waterson, AG; Smethurst, C; Kessler, D; Böttcher, J; Mayer, M; Gmaschitz, G; Phan, J; Little, A; Abbott, JR; Sun, Q; Gmachl, M; Rudolph, D; Arnhof, H; Rumpel, K; Savarese, F; Gerstberger, T; Mischerikow, N; Treu, M; Herdeis, L; Wunberg, T; Gollner, A; Weinstabl, H; Mantoulidis, A; Krämer, O; McConnell, DB; W Fesik, S Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS J Med Chem65:14614-14629 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50607576 |
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| n/a |
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| Name | BDBM50607576 |
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| Synonyms: | CHEMBL5218642 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37N9O2S |
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| Mol. Mass. | 587.739 |
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| SMILES | C[C@H]1CN(C)CCN1c1cc(cc(n1)-c1noc(n1)[C@@]1(C)CCCc2sc(N)c(C#N)c12)N1CCN(CC1)C(=O)C=C |r| |
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| Structure | 
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