Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50191551

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_376971 (CHEMBL853374)

15±n/a nM

Citation

Tian, X; Field, TB; Switzer, AG; Mazur, AW; Ebetino, FH; Wos, JA; Berberich, SM; Jayasinghe, LR; Obringer, CM; Dowty, ME; Pinney, BB; Farmer, JA; Crossdoersen, D; Sheldon, RJ Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach. J Med Chem49:4745-61 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

34717.23

Organism:

Homo sapiens (Human)

Description:

Q01726

Residue:

317

Sequence:

MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW

BDBM50191551

n/a

Name

BDBM50191551

Synonyms:

(2R,4R)-1-((R)-2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-3-phenylpropanoyl)-N-(2-guanidinoethyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine-2-carboxamide | CHEMBL209587

Type

Small organic molecule

Emp. Form.

C34H41N9O4

Mol. Mass.

639.7472

SMILES

N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](C[C@@H]1C(=O)NCCN=C(N)N)OCc1ccc2ccccc2c1 |wU:25.28,11.11,23.37,wD:1.0,(15.6,-11.59,;14.27,-12.36,;12.94,-11.59,;12.94,-10.05,;11.68,-9.15,;12.16,-7.69,;13.7,-7.69,;14.17,-9.15,;14.27,-13.9,;15.61,-14.67,;12.94,-14.67,;12.94,-16.21,;11.61,-16.99,;10.27,-16.22,;8.93,-16.99,;7.6,-16.22,;7.6,-14.67,;8.93,-13.9,;10.27,-14.67,;14.28,-16.98,;15.61,-16.21,;14.28,-18.52,;13.03,-19.43,;13.51,-20.89,;15.05,-20.89,;15.52,-19.43,;16.87,-18.68,;16.89,-17.14,;18.19,-19.47,;19.54,-18.72,;20.86,-19.51,;22.2,-18.76,;23.52,-19.56,;24.87,-18.81,;23.5,-21.1,;12.6,-22.14,;13.23,-23.55,;12.47,-24.88,;13.24,-26.21,;12.48,-27.54,;10.93,-27.55,;10.17,-28.87,;8.64,-28.88,;7.87,-27.55,;8.63,-26.22,;10.17,-26.22,;10.92,-24.88,)|

Structure