Reaction Details | |||
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Target | Melanocortin receptor 4 | ||
Ligand | BDBM50191565 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_376976 (CHEMBL871437) | ||
EC50 | 9±n/a nM | ||
Citation | Tian, X; Field, TB; Switzer, AG; Mazur, AW; Ebetino, FH; Wos, JA; Berberich, SM; Jayasinghe, LR; Obringer, CM; Dowty, ME; Pinney, BB; Farmer, JA; Crossdoersen, D; Sheldon, RJ Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach. J Med Chem49:4745-61 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocortin receptor 4 | |||
Name: | Melanocortin receptor 4 | ||
Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) | ||
Type: | Enzyme | ||
Mol. Mass.: | 36949.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P32245 | ||
Residue: | 332 | ||
Sequence: |
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BDBM50191565 | |||
n/a | |||
Name | BDBM50191565 | ||
Synonyms: | (S)-2-acetamido-N-((R)-1-((2R,4S)-2-(3-guanidinopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-3-(1H-imidazol-4-)propanamide | CHEMBL213747 | ||
Type | Small organic molecule | ||
Emp. Form. | C36H44N8O4 | ||
Mol. Mass. | 652.7858 | ||
SMILES | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](C[C@H]1CCCN=C(N)N)OCc1ccc2ccccc2c1 |wU:14.14,4.3,wD:28.31,26.38,(8.94,3.78,;10.28,3.01,;10.28,1.47,;11.61,3.78,;12.95,3.01,;14.28,3.78,;14.28,5.32,;13.02,6.23,;13.5,7.69,;15.04,7.7,;15.51,6.23,;12.95,1.47,;14.28,.7,;11.61,.7,;11.62,-.84,;10.28,-1.61,;8.95,-.84,;7.61,-1.61,;6.27,-.84,;6.28,.7,;7.6,1.47,;8.94,.71,;12.95,-1.61,;14.28,-.84,;12.95,-3.15,;11.7,-4.06,;12.18,-5.52,;13.72,-5.52,;14.2,-4.05,;15.54,-3.3,;16.86,-4.1,;18.21,-3.35,;19.53,-4.14,;20.88,-3.39,;22.2,-4.18,;20.9,-1.85,;11.28,-6.77,;11.91,-8.17,;11.14,-9.51,;11.91,-10.83,;11.15,-12.17,;9.6,-12.18,;8.84,-13.5,;7.31,-13.51,;6.54,-12.17,;7.31,-10.84,;8.84,-10.84,;9.6,-9.51,)| | ||
Structure |