Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 1 |
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Ligand | BDBM50192469 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_381625 (CHEMBL869159) |
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Ki | 87±n/a nM |
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Citation | Rejman, D; Olesiak, M; Chen, L; Patterson, SE; Wilson, D; Jayaram, HN; Hedstrom, L; Pankiewicz, KW Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase. J Med Chem49:5018-22 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 1 |
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Name: | Inosine-5'-monophosphate dehydrogenase 1 |
Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55407.70 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH1 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
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BDBM50192469 |
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n/a |
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Name | BDBM50192469 |
Synonyms: | CHEMBL215311 | P1-(adenosin-5'-yl)methylenephospho-P2-[7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one]phosphonate |
Type | Small organic molecule |
Emp. Form. | C23H29N5O14P2 |
Mol. Mass. | 661.449 |
SMILES | COc1c(C)c2COC(=O)c2c(O)c1CCOP(O)(=O)COP(O)(=O)OCC1OC([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12 |
Structure |
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