| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase family 1 member A3 |
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| Ligand | BDBM50406339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2266495 |
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| IC50 | <100±n/a nM |
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| Citation |  Kargbo, RB Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer. ACS Med Chem Lett14:131-132 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase family 1 member A3 |
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| Name: | Aldehyde dehydrogenase family 1 member A3 |
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| Synonyms: | AL1A3_HUMAN | ALDH1A3 | ALDH6 | Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56110.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109700 |
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| Residue: | 512 |
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| Sequence: | MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
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| BDBM50406339 |
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| n/a |
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| Name | BDBM50406339 |
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| Synonyms: | CHEMBL5278448 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19FN4O3S |
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| Mol. Mass. | 438.475 |
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| SMILES | OC1CN(C1)c1nc(c(s1)C(=O)Nc1ccc2NC(=O)CCc2c1)-c1cccc(F)c1 |
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| Structure | 
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