Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50559516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2267441 |
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Ki | 12±n/a nM |
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Citation | Flick, AC; Leverett, CA; Ding, HX; McInturff, E; Fink, SJ; Mahapatra, S; Carney, DW; Lindsey, EA; DeForest, JC; France, SP; Berritt, S; Bigi-Botterill, SV; Gibson, TS; Liu, Y; O'Donnell, CJ Synthetic Approaches to the New Drugs Approved during 2019. J Med Chem64:3604-3657 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50559516 |
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n/a |
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Name | BDBM50559516 |
Synonyms: | GSK-189075 | GSK-189075A | GSK189075A | Remogliflozin etabonate |
Type | Small organic molecule |
Emp. Form. | C26H38N2O9 |
Mol. Mass. | 522.5879 |
SMILES | [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| |
Structure |
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