Reaction Details |
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Target | Acid-sensing ion channel 1 |
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Ligand | BDBM50408500 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2267837 |
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IC50 | 972±n/a nM |
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Citation | Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult. J Med Chem64:8333-8353 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Acid-sensing ion channel 1 |
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Name: | Acid-sensing ion channel 1 |
Synonyms: | ACCN2 | ASIC1 | ASIC1_HUMAN | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | Brain sodium channel 2 |
Type: | PROTEIN |
Mol. Mass.: | 59900.27 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1495930 |
Residue: | 528 |
Sequence: | MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
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BDBM50408500 |
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n/a |
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Name | BDBM50408500 |
Synonyms: | CHEMBL5278611 |
Type | Small organic molecule |
Emp. Form. | C23H26Br2N10 |
Mol. Mass. | 602.328 |
SMILES | Br.Br.C1CN=C(N\N=C/c2ccc(cc2)-c2cc([nH]n2)-c2ccc(\C=N\NC3=NCCN3)cc2)N1 |t:2,27| |
Structure |
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