| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50193688 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_421374 (CHEMBL856556) |
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| EC50 | 56±n/a nM |
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| Citation |  Jiang, J; Hoang, M; Young, JR; Chaung, D; Eid, R; Turner, C; Lin, P; Tong, X; Wang, J; Tan, C; Feighner, S; Palyha, O; Hreniuk, DL; Pan, J; Sailer, AW; MacNeil, DJ; Howard, A; Shearman, L; Stribling, S; Camacho, R; Strack, A; Van der Ploeg, LH; Goulet, MT; DeVita, RJ 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorg Med Chem Lett16:5270-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39075.64 |
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| Organism: | RAT |
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| Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
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| Residue: | 353 |
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| Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50193688 |
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| n/a |
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| Name | BDBM50193688 |
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| Synonyms: | CHEMBL217487 | N-(2-(azetidin-1-yl)quinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)propanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F3N3O |
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| Mol. Mass. | 399.4089 |
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| SMILES | FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC2)cc1 |
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| Structure | 
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