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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Translocator protein | ||
| Ligand | BDBM50131729 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2268394 | ||
| IC50 | 2.2±n/a nM | ||
| Citation |  Giordani, A; Menziani, MC; Moresco, RM; Matarrese, M; Paolino, M; Saletti, M; Giuliani, G; Anzini, M; Cappelli, A Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria. J Med Chem64:9649-9676 (2021) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Translocator protein | |||
| Name: | Translocator protein | ||
| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo | ||
| Type: | Mitochondrion membrane protein | ||
| Mol. Mass.: | 18945.84 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. | ||
| Residue: | 169 | ||
| Sequence: |
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| BDBM50131729 | |||
| n/a | |||
| Name | BDBM50131729 | ||
| Synonyms: | 4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxylic acid benzyl-methyl-amide | CHEMBL325820 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H21FN2O | ||
| Mol. Mass. | 384.4454 | ||
| SMILES | CN(Cc1ccccc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1F |(11.02,-3.02,;11.02,-1.48,;12.35,-.71,;13.68,-1.47,;15,-.68,;16.34,-1.45,;16.36,-2.99,;15.03,-3.76,;13.68,-3.01,;9.68,-.72,;9.67,.82,;8.35,-1.5,;7.01,-.73,;5.69,-1.52,;4.35,-.75,;3.02,-1.52,;3.02,-3.06,;4.35,-3.83,;5.69,-3.06,;7.03,-3.83,;8.36,-3.04,;9.69,-3.81,;7.03,-5.35,;5.69,-6.12,;5.69,-7.66,;7.03,-8.43,;8.36,-7.65,;8.36,-6.12,;9.69,-5.34,)| | ||
| Structure | 
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