| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50414477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2269130 |
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| IC50 | 8.0±n/a nM |
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| Citation |  Chen, L; Su, M; Jin, Q; Wang, W; Wang, CG; Assani, I; Wang, MX; Zhao, SF; Lv, SM; Wang, JW; Sun, B; Li, Y; Liao, ZX Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor ?t Inverse Agonist. J Med Chem64:16106-16131 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50414477 |
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| n/a |
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| Name | BDBM50414477 |
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| Synonyms: | CHEMBL5291188 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35NO5S |
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| Mol. Mass. | 473.625 |
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| SMILES | CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc2O[C@H](CC(O)c2c1)C1CCOCC1 |r| |
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| Structure | 
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