| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknB |
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| Ligand | BDBM50421685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2269371 |
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| Kd | 73±n/a nM |
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| Citation |  Wlodarchak, N; Feltenberger, JB; Ye, Z; Beczkiewicz, J; Procknow, R; Yan, G; King, TM; Golden, JE; Striker, R Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry. ACS Med Chem Lett12:228-235 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PknB |
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| Name: | Serine/threonine-protein kinase PknB |
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| Synonyms: | PKNB_MYCTU | pknB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66497.93 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_774233 |
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| Residue: | 626 |
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| Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
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| BDBM50421685 |
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| n/a |
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| Name | BDBM50421685 |
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| Synonyms: | CHEMBL5280226 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21F3N6 |
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| Mol. Mass. | 438.4482 |
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| SMILES | CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cccc(c2)C#N)cc1C(F)(F)F |
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| Structure | 
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