Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine deaminase (Homo sapiens (Human)) | BDBM22925 ((8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113877 BindingDB Entry DOI: 10.7270/Q2PK0M78 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Homo sapiens (Human)) | BDBM50367032 (COFORMYCIN) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113877 BindingDB Entry DOI: 10.7270/Q2PK0M78 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17355 (1,2,4-Triazole Compound, 13 | 5-(benzylsulfanyl)-N...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0400 | -58.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17428 (1,2,4-Triazole Compound, 86 | N-[5-(benzylsulfanyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17388 (1,2,4-Triazole Compound, 46 | 5-(benzylsulfanyl)-N...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17365 (1,2,4-Triazole Compound, 23 | 5-(benzylsulfanyl)-N...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0700 | -57.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17390 (1,2,4-Triazole Compound, 48 | 5-{[(2-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17362 (1,2,4-Triazole Compound, 20 | 5-[(3-methylbut-2-en...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.150 | -55.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17395 (1,2,4-Triazole Compound, 53 | N-(4-methoxyphenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17358 (1,2,4-Triazole Compound, 16 | 5-{[(2-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.230 | -54.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299269 (US9593113, Example 34) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lethal factor (Bacillus anthracis) | BDBM50601786 (CHEMBL5180162) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113877 BindingDB Entry DOI: 10.7270/Q2PK0M78 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17430 (1,2,4-Triazole Compound, 88 | N-(5-{[(2-fluorophen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM21281 ((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Binding affinity of compound was determined against to human cannabinoid receptor 2 in chinese hamster ovary cells | J Med Chem 46: 2110-6 (2003) Article DOI: 10.1021/jm020329q BindingDB Entry DOI: 10.7270/Q2J67HPG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299305 (US9593113, Example 69) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299270 (US9593113, Example 35 | US9593113, Example 47) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17411 (1,2,4-Triazole Compound, 69 | methyl 4-[(5-{[(2-fl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299266 (US9593113, Example 31) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17377 (1,2,4-Triazole Compound, 35 | 5-(benzylsulfanyl)-N...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17431 (1,2,4-Triazole Compound, 89 | N-(5-{[(3,4-difluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17352 (1,2,4-Triazole Compound, 6 | 5-(benzylsulfanyl)-N-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.5 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299293 (US9593113, Example 57 | US9593113, Example 65) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17416 (1,2,4-Triazole Compound, 74 | methyl 4-({5-[(3-met...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM50291823 (19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories Curated by ChEMBL | Assay Description Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation. | J Med Chem 32: 880-4 (1989) BindingDB Entry DOI: 10.7270/Q2ZK5FNZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17385 (1,2,4-Triazole Compound, 43 | N-(4-chlorophenyl)-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Sus scrofa (pig)) | BDBM26526 ((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113877 BindingDB Entry DOI: 10.7270/Q2PK0M78 | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome b (Sus scrofa) | BDBM50487138 (CHEMBL2251795) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Central China Normal University Curated by ChEMBL | Assay Description Inhibition of Sus scrofa (pig) heart cytochrome bc1 complex using DBH2 as substrate by spectrophotometric analysis | J Am Chem Soc 132: 185-94 (2010) Article DOI: 10.1021/ja905756c BindingDB Entry DOI: 10.7270/Q27W6G35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299318 (US9593113, Example 82) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299268 (US9593113, Example 33) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17380 (1,2,4-Triazole Compound, 38 | N-(4-chlorophenyl)-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299304 (US9593113, Example 68) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17368 (1,2,4-Triazole Compound, 26 | 5-{[(2-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.650 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM351897 ((S)-5-(2-(1H-Imidazo[4,5-b]pyrazin-2-yl)propan-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description In order to measure the binding of compounds on the glucocorticoid receptor a commercially available kit was used (Glucocorticoid receptor competitor... | US Patent US9796720 (2017) BindingDB Entry DOI: 10.7270/Q2H41TJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM351895 ((S)-5-(2-(1H-Imidazo[4,5-b]pyrazin-2-yl)propan-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description In order to measure the binding of compounds on the glucocorticoid receptor a commercially available kit was used (Glucocorticoid receptor competitor... | US Patent US9796720 (2017) BindingDB Entry DOI: 10.7270/Q2H41TJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM50291822 (19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories Curated by ChEMBL | Assay Description Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation. | J Med Chem 32: 880-4 (1989) BindingDB Entry DOI: 10.7270/Q2ZK5FNZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17408 (1,2,4-Triazole Compound, 66 | methyl 4-{[5-(benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50048342 (CHEMBL3315064 | US9593113, Example 30) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17354 (1,2,4-Triazole Compound, 12 | N-phenyl-5-[(thiophe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.75 | -51.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM351893 ((S)-2-(9-Fluoro-2-(4-(1-methyl-1H-tetrazol-5-yl)ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description In order to measure the binding of compounds on the glucocorticoid receptor a commercially available kit was used (Glucocorticoid receptor competitor... | US Patent US9796720 (2017) BindingDB Entry DOI: 10.7270/Q2H41TJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17418 (1,2,4-Triazole Compound, 76 | methyl 4-[(5-{[(5-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299271 (US9593113, Example 36) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299281 (US9593113, Example 45) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM351896 ((S)-5-(2-(1H-Imidazo[4,5-b]pyrazin-2-yl)propan-2-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description In order to measure the binding of compounds on the glucocorticoid receptor a commercially available kit was used (Glucocorticoid receptor competitor... | US Patent US9796720 (2017) BindingDB Entry DOI: 10.7270/Q2H41TJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299270 (US9593113, Example 35 | US9593113, Example 47) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50476859 (CHEMBL232938) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Displacement of [3H]succinamide from gamma secretase in THP1 cell membranes | Bioorg Med Chem Lett 17: 3910-5 (2007) Article DOI: 10.1016/j.bmcl.2007.04.102 BindingDB Entry DOI: 10.7270/Q2M90CFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17414 (1,2,4-Triazole Compound, 72 | methyl 4-({5-[(pyrid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17413 (1,2,4-Triazole Compound, 71 | methyl 4-({5-[(pyrid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM17405 (1,2,4-Triazole Compound, 63 | N-(3,4-dimethoxyphen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi... | J Med Chem 50: 3777-85 (2007) Article DOI: 10.1021/jm061182w BindingDB Entry DOI: 10.7270/Q2B856D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299279 (US9593113, Example 43) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM299278 (US9593113, Example 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Binding Assay (I):In order to assess the affinity of test compounds for the human glucocorticoid receptor, a commercially available kit was used (Glu... | US Patent US9593113 (2017) BindingDB Entry DOI: 10.7270/Q2833V3Z | |||||||||||
More data for this Ligand-Target Pair |
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