| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50196447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_431934 (CHEMBL917829) |
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| EC50 | >100000±n/a nM |
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| Citation |  Kaur, N; Monga, V; Lu, X; Gershengorn, MC; Jain, R Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem15:433-43 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | Thyrotropin-releasing hormone receptor 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39044.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_532304 |
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| Residue: | 352 |
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| Sequence: | MDGPSNVSLIHGDTTLGLPEYKVVSVFLVLLVCTLGIVGNAMVILVVLTSRDMHTPTNCY
LVSLALADLLVLLAAGLPNVSDSLVGHWIYGRAGCLGITYFQYLGINVSSFSILAFTVER
YIAICHPLRAQTVCTVARAKRIIAGIWGVTSLYCLLWFFLVDLNVRDNQRLECGYKVPRG
LYLPIYLLDFAVFFIGPLLVTLVLYGLIGRILFQSPLSQEAWQKERQPHGQSEAAPGNCS
RAKSSRKQATRMLAVVVLLFAVLWTPYRTLVLLNSFVAQPFLDPWVLLFCRTCVYTNSAV
NPVVYSLMSQKFRAAFLKLCWCRAAGPQRRAARVLTSNYSAAQETSEGTEKM
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| BDBM50196447 |
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| n/a |
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| Name | BDBM50196447 |
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| Synonyms: | (2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarboxamido]-3-(2-cyclohexyl-1H-imidazolyl)propanoyl]-azalone-2-carboxamide | CHEMBL437735 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H34N6O4 |
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| Mol. Mass. | 458.5539 |
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| SMILES | NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CCCCC1)NC(=O)[C@@H]1CCCC(=O)N1 |
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| Structure | 
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