| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50196458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_431931 (CHEMBL917826) |
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| Ki | >100000±n/a nM |
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| Citation |  Kaur, N; Monga, V; Lu, X; Gershengorn, MC; Jain, R Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem15:433-43 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | TRFR_HUMAN | TRH-R | TRHR | Thyroliberin receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45093.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_431933 |
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| Residue: | 398 |
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| Sequence: | MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
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| BDBM50196458 |
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| n/a |
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| Name | BDBM50196458 |
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| Synonyms: | (2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-6-oxohexahydro-2-pyridinylcarboxamido]azolane-propanoyl}azolane-2-carboxamide | CHEMBL389037 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N6O4 |
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| Mol. Mass. | 466.5328 |
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| SMILES | NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)cn1)NC(=O)[C@@H]1CCCC(=O)N1 |
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| Structure | 
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