| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM15918 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453169 (CHEMBL902320) |
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| IC50 | 24±n/a nM |
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| Citation |  Liu, G; Zhao, H; Liu, B; Xin, Z; Liu, M; Serby, MD; Lubbers, NL; Widomski, DL; Polakowski, JS; Beno, DW; Trevillyan, JM; Sham, HL Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases. Bioorg Med Chem Lett17:495-500 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM15918 |
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| n/a |
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| Name | BDBM15918 |
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| Synonyms: | 2-pyridinecarboxamide deriv. 12 | 4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide | 4-amino-5-chloro-6-ethoxy-N-[(4-methanesulfonylphenyl)methyl]pyridine-2-carboxamide | CHEMBL377383 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18ClN3O4S |
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| Mol. Mass. | 383.85 |
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| SMILES | CCOc1nc(cc(N)c1Cl)C(=O)NCc1ccc(cc1)S(C)(=O)=O |
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| Structure | 
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