| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 7 |
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| Ligand | BDBM50609495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2278032 |
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| IC50 | 2638±n/a nM |
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| Citation |  Yang, B; Zhang, H; Li, N; Gao, L; Jiang, H; Kan, W; Yuan, H; Li, J; Zhao, D; Xiong, B; Zhou, Y; Guo, D; Liu, T Discovery of Novel J Med Chem65:15770-15788 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 7 |
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| Name: | Cyclin-dependent kinase 7 |
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| Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 39047.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 346 |
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| Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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| BDBM50609495 |
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| n/a |
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| Name | BDBM50609495 |
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| Synonyms: | CHEMBL5283085 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27N5O2 |
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| Mol. Mass. | 477.557 |
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| SMILES | OC[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)Cc1ccccc1 |r| |
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| Structure | 
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