Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM50610114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2280203 |
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IC50 | 2500±n/a nM |
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Citation | Vandeveer, GH; Arduini, RM; Baker, DP; Barry, K; Bohnert, T; Bowden-Verhoek, JK; Conlon, P; Cullen, PF; Guan, B; Jenkins, TJ; Liao, SY; Lin, L; Liu, YT; Marcotte, D; Mertsching, E; Metrick, CM; Negrou, E; Powell, N; Scott, D; Silvian, LF; Hopkins, BT Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett80:0 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM50610114 |
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n/a |
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Name | BDBM50610114 |
Synonyms: | CHEMBL5266164 |
Type | Small organic molecule |
Emp. Form. | C20H20F4N6O |
Mol. Mass. | 436.406 |
SMILES | Fc1cc(NCC(=O)N2CCC[C@H](C2)Nc2ncnc3[nH]ccc23)cc(c1)C(F)(F)F |r| |
Structure |
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