Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Ligand | BDBM50197401 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453208 (CHEMBL902362) | ||
IC50 | >100000±n/a nM | ||
Citation | Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. Bioorg Med Chem Lett17:527-32 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase type 2 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_MOUSE | Hsd11b2 | Hsd11k | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | ||
Type: | Enzyme | ||
Mol. Mass.: | 42201.46 | ||
Organism: | Mus musculus (mouse) | ||
Description: | Purified recombinant mouse 11beta-HSD2. | ||
Residue: | 386 | ||
Sequence: |
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BDBM50197401 | |||
n/a | |||
Name | BDBM50197401 | ||
Synonyms: | 2-methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide | CHEMBL241719 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H28N2O4S | ||
Mol. Mass. | 392.512 | ||
SMILES | CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O |w:16.23,14.25,18.18,wU:13.13,wD:20.26,TLB:13:14:21:17.18.19,12:13:21.16.17:19,THB:15:16:19:22.14.13,15:14:21.16.17:19,13:18:21:22.15.14,TEB:17:18:22:21.16.15,(1.42,4.21,;2.23,2.91,;3.05,1.6,;3.56,3.69,;4.9,2.93,;4.91,1.39,;6.24,.63,;7.57,1.41,;7.56,2.96,;6.22,3.71,;.95,2.06,;1.04,.52,;-.43,2.74,;-1.71,1.89,;-1.72,.36,;-2.74,-.92,;-4.14,-.35,;-4.15,1.24,;-3.11,2.47,;-4.46,1.99,;-4.45,.51,;-5.64,-.77,;-3.12,.02,;-5.94,.92,;-7.44,1.32,;-5.54,2.4,;-6.35,-.57,)| | ||
Structure |