| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50197775 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453280 (CHEMBL902435) |
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| IC50 | 480±n/a nM |
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| Citation |  Wei, RG; Arnaiz, DO; Chou, YL; Davey, D; Dunning, L; Lee, W; Lu, SF; Onuffer, J; Ye, B; Phillips, G CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives. Bioorg Med Chem Lett17:231-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50197775 |
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| n/a |
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| Name | BDBM50197775 |
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| Synonyms: | (2E)-2-{5-bromo-2-[(4-cyanobenzyl)oxy]benzylidene}hydrazinecarboximidamide | CHEMBL240636 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14BrN5O |
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| Mol. Mass. | 372.219 |
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| SMILES | [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-c1cc(Br)ccc1-[#8]-[#6]-c1ccc(cc1)C#N |w:5.5| |
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| Structure | 
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