| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50197914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432393 (CHEMBL915971) |
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| IC50 | 11000±n/a nM |
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| Citation |  Iwakubo, M; Takami, A; Okada, Y; Kawata, T; Tagami, Y; Sato, M; Sugiyama, T; Fukushima, K; Taya, S; Amano, M; Kaibuchi, K; Iijima, H Design and synthesis of rho kinase inhibitors (III). Bioorg Med Chem15:1022-33 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50197914 |
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| n/a |
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| Name | BDBM50197914 |
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| Synonyms: | CHEMBL375556 | N-(1-(4-chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5-amine | N-[1-(4-chlorobenzyl)-3-pyrrolidyl]-N-(5-isoquinolyl)amine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20ClN3 |
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| Mol. Mass. | 337.846 |
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| SMILES | Clc1ccc(CN2CCC(C2)Nc2cccc3cnccc23)cc1 |
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| Structure | 
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