Reaction Details |
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Target | Potassium voltage-gated channel subfamily A member 5 |
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Ligand | BDBM50199060 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_411693 (CHEMBL913527) |
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IC50 | 260±n/a nM |
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Citation | Trotter, BW; Nanda, KK; Kett, NR; Regan, CP; Lynch, JJ; Stump, GL; Kiss, L; Wang, J; Spencer, RH; Kane, SA; White, RB; Zhang, R; Anderson, KD; Liverton, NJ; McIntyre, CJ; Beshore, DC; Hartman, GD; Dinsmore, CJ Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. J Med Chem49:6954-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily A member 5 |
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Name: | Potassium voltage-gated channel subfamily A member 5 |
Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
Type: | Enzyme |
Mol. Mass.: | 67222.47 |
Organism: | Homo sapiens (Human) |
Description: | P22460 |
Residue: | 613 |
Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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BDBM50199060 |
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n/a |
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Name | BDBM50199060 |
Synonyms: | 4-(3-fluorophenyl)-6-methoxy-1-(4-methyl-1H-imidazol-1-yl)isoquinoline-3-carbonitrile | CHEMBL215818 |
Type | Small organic molecule |
Emp. Form. | C21H15FN4O |
Mol. Mass. | 358.3684 |
SMILES | COc1ccc2c(nc(C#N)c(-c3cccc(F)c3)c2c1)-n1cnc(C)c1 |
Structure |
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