Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50126370 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458901 (CHEMBL923872) |
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Ki | 57±n/a nM |
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Citation | Gilbert, KM; Boos, TL; Dersch, CM; Greiner, E; Jacobson, AE; Lewis, D; Matecka, D; Prisinzano, TE; Zhang, Y; Rothman, RB; Rice, KC; Venanzi, CA DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorg Med Chem15:1146-59 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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BDBM50126370 |
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n/a |
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Name | BDBM50126370 |
Synonyms: | 2-((4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperazin-1-yl)methyl)-3,4-dihydronaphthalen-1(2H)-one | 2-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one | CHEMBL28867 |
Type | Small organic molecule |
Emp. Form. | C30H32F2N2O2 |
Mol. Mass. | 490.5841 |
SMILES | Fc1ccc(cc1)C(OCCN1CCN(CC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1 |
Structure |
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