Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent dopamine transporter |
---|
Ligand | BDBM50126359 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_458901 (CHEMBL923872) |
---|
Ki | 53±n/a nM |
---|
Citation | Gilbert, KM; Boos, TL; Dersch, CM; Greiner, E; Jacobson, AE; Lewis, D; Matecka, D; Prisinzano, TE; Zhang, Y; Rothman, RB; Rice, KC; Venanzi, CA DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorg Med Chem15:1146-59 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent dopamine transporter |
---|
Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
BDBM50126359 |
---|
n/a |
---|
Name | BDBM50126359 |
Synonyms: | 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-((6-methoxy-3,4-dihydronaphthalen-2-yl)methyl)piperazine | 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(6-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-piperazine | CHEMBL28414 |
Type | Small organic molecule |
Emp. Form. | C31H34F2N2O2 |
Mol. Mass. | 504.6107 |
SMILES | COc1ccc2C=C(CN3CCN(CCOC(c4ccc(F)cc4)c4ccc(F)cc4)CC3)CCc2c1 |t:6| |
Structure |
|