| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50613319 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2291890 |
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| IC50 | >1.000000±n/a nM |
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| Citation |  Kargbo, RB Discovery of Selective and Potent KRAS ACS Med Chem Lett14:689-691 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
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| BDBM50613319 |
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| n/a |
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| Name | BDBM50613319 |
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| Synonyms: | CHEMBL5273771 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30F4N6O2 |
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| Mol. Mass. | 558.5704 |
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| SMILES | Oc1ccc(c(c1)-c1ncc2c(nc(OCC34CCCN3CCC4)nc2c1F)N1CC2CCC1CN2)C(F)(F)F |
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| Structure | 
|
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