| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50200256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_408430 (CHEMBL908865) |
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| IC50 | 1320±n/a nM |
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| Citation |  Ulven, T; Receveur, JM; Grimstrup, M; Rist, Ø; Frimurer, TM; Gerlach, LO; Mathiesen, JM; Kostenis, E; Uller, L; Högberg, T Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem49:6638-41 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50200256 |
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| n/a |
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| Name | BDBM50200256 |
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| Synonyms: | 4-fluoro-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid | CHEMBL217352 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13FN2O4 |
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| Mol. Mass. | 340.3052 |
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| SMILES | OC(=O)COc1ccc(F)cc1C(=O)c1cnn(c1)-c1ccccc1 |
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| Structure | 
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