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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 5 subunit alpha | ||
| Ligand | BDBM50613993 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2295213 | ||
| IC50 | >50000±n/a nM | ||
| Citation |  Peukert, S; Gulgeze Efthymiou, HB; Mo, R; Peng, Y; Ma, F; Barbe, G; Bebernitz, G; Fridrich, C; Buono, C; Williams, ET; Daniels, T; Li, L; Zhang, X; Adachi, Y; Abe, M; Taggart, AKP Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation. Bioorg Med Chem Lett85:0 (2023) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 5 subunit alpha | |||
| Name: | Sodium channel protein type 5 subunit alpha | ||
| Synonyms: | HH1 | SCN5A | SCN5A_HUMAN | Sodium channel alpha subunit | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 | Sodium channel protein type V alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.5 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 226908.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14524 | ||
| Residue: | 2016 | ||
| Sequence: |
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| BDBM50613993 | |||
| n/a | |||
| Name | BDBM50613993 | ||
| Synonyms: | CHEMBL5286246 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H8Cl2FN3O | ||
| Mol. Mass. | 348.159 | ||
| SMILES | Cc1cc(=O)c2c(F)cncc2n1-c1c(Cl)cc(cc1Cl)C#N |(3.33,-1.54,;2,-2.31,;2,-3.85,;.66,-4.62,;.66,-6.16,;-.67,-3.85,;-2,-4.62,;-2,-6.16,;-3.33,-3.86,;-3.33,-2.31,;-2,-1.54,;-.67,-2.31,;.66,-1.54,;.66,0,;-.67,.77,;-2.01,0,;-.67,2.31,;.66,3.08,;1.99,2.31,;2,.78,;3.33,.01,;.66,4.62,;.66,6.16,)| | ||
| Structure | 
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