Reaction Details | |||
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Target | Voltage-dependent L-type calcium channel subunit alpha-1C | ||
Ligand | BDBM50613993 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2295214 | ||
IC50 | >50000±n/a nM | ||
Citation | Peukert, S; Gulgeze Efthymiou, HB; Mo, R; Peng, Y; Ma, F; Barbe, G; Bebernitz, G; Fridrich, C; Buono, C; Williams, ET; Daniels, T; Li, L; Zhang, X; Adachi, Y; Abe, M; Taggart, AKP Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation. Bioorg Med Chem Lett85:0 (2023) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Voltage-dependent L-type calcium channel subunit alpha-1C | |||
Name: | Voltage-dependent L-type calcium channel subunit alpha-1C | ||
Synonyms: | CAC1C_HUMAN | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel (Type L) | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel alpha-1C subunit | Voltage-gated calcium channel | Voltage-gated calcium channel subunit alpha Cav1.2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 248979.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Calcium channel (Type L) 0 HUMAN::Q13936 | ||
Residue: | 2221 | ||
Sequence: |
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BDBM50613993 | |||
n/a | |||
Name | BDBM50613993 | ||
Synonyms: | CHEMBL5286246 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H8Cl2FN3O | ||
Mol. Mass. | 348.159 | ||
SMILES | Cc1cc(=O)c2c(F)cncc2n1-c1c(Cl)cc(cc1Cl)C#N |(3.33,-1.54,;2,-2.31,;2,-3.85,;.66,-4.62,;.66,-6.16,;-.67,-3.85,;-2,-4.62,;-2,-6.16,;-3.33,-3.86,;-3.33,-2.31,;-2,-1.54,;-.67,-2.31,;.66,-1.54,;.66,0,;-.67,.77,;-2.01,0,;-.67,2.31,;.66,3.08,;1.99,2.31,;2,.78,;3.33,.01,;.66,4.62,;.66,6.16,)| | ||
Structure |