| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas |
|---|
| Ligand | BDBM50614269 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2296187 |
|---|
| IC50 | 43±n/a nM |
|---|
| Citation |  Kargbo, RB Targeting the "Undruggable" Driver Protein, KRAS ACS Med Chem Lett14:365-366 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| GTPase KRas |
|---|
| Name: | GTPase KRas |
|---|
| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 21656.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1476955 |
|---|
| Residue: | 189 |
|---|
| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
|
|
|
|---|
| BDBM50614269 |
|---|
| n/a |
|---|
| Name | BDBM50614269 |
|---|
| Synonyms: | CHEMBL5273122 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H32F3N5O3 |
|---|
| Mol. Mass. | 615.6448 |
|---|
| SMILES | Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CCCC3(CCO3)C2)c2c(C#C)c(F)ccc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
