| Reaction Details |
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 | Report a problem with these data |
| Target | Son of sevenless homolog 1 |
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| Ligand | BDBM50614625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2298025 |
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| IC50 | 8.5±n/a nM |
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| Citation |  Jiang, H; Fan, Y; Wang, X; Wang, J; Yang, H; Fan, W; Tang, C Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors. Bioorg Med Chem Lett88:0 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Son of sevenless homolog 1 |
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| Name: | Son of sevenless homolog 1 |
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| Synonyms: | SOS-1 | SOS1 | SOS1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 152470.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_839705 |
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| Residue: | 1333 |
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| Sequence: | MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
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| BDBM50614625 |
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| n/a |
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| Name | BDBM50614625 |
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| Synonyms: | CHEMBL5290935 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4O3S |
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| Mol. Mass. | 464.58 |
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| SMILES | COc1cc2ncnc(NC(C)c3ccc(s3)-c3ccccc3CNCCO)c2cc1OC |
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| Structure | 
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