Reaction Details |
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Target | Trypanothione reductase |
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Ligand | BDBM50615394 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2302232 |
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Ki | 2000±n/a nM |
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Citation | Jagu, E; Pomel, S; Pethe, S; Loiseau, PM; Labručre, R Polyamine-based analogs and conjugates as antikinetoplastid agents. Eur J Med Chem139:982-1015 (2017) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Trypanothione reductase |
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Name: | Trypanothione reductase |
Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
Type: | Homodimer; oxidoreductase |
Mol. Mass.: | 53868.26 |
Organism: | Trypanosoma cruzi |
Description: | n/a |
Residue: | 492 |
Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
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BDBM50615394 |
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n/a |
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Name | BDBM50615394 |
Synonyms: | CHEMBL5266592 |
Type | Small organic molecule |
Emp. Form. | C54H70N8O8 |
Mol. Mass. | 959.1824 |
SMILES | CCCNCCCNC(=O)CNC(=O)[C@H](CCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)NCC(=O)NCCCNCCC)NC(=O)OCC1c2ccccc2-c2ccccc12 |r| |
Structure |
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