| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50074750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_423514 (CHEMBL910532) |
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| Ki | 4.7±n/a nM |
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| Citation |  Monn, JA; Massey, SM; Valli, MJ; Henry, SS; Stephenson, GA; Bures, M; Hérin, M; Catlow, J; Giera, D; Wright, RA; Johnson, BG; Andis, SL; Kingston, A; Schoepp, DD Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors. J Med Chem50:233-40 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98889.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50074750 |
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| n/a |
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| Name | BDBM50074750 |
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| Synonyms: | (1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid | CHEMBL8839 | LY-389795 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9NO4S |
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| Mol. Mass. | 203.216 |
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| SMILES | N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |
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| Structure | 
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