Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50288820 ((S)-2-{(S)-4-[4-(2,4-Diamino-pyrimidin-5-yl)-butyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 0.00500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against Recombinant human dihydrofolate reductase (DHFR) | Bioorg Med Chem Lett 6: 473-476 (1996) Article DOI: 10.1016/0960-894X(96)00053-4 BindingDB Entry DOI: 10.7270/Q2GQ6XQ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50288821 ((S)-2-{(S)-4-[3-(2,4-Diamino-pyrimidin-5-yl)-propy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against Recombinant human dihydrofolate reductase (DHFR) | Bioorg Med Chem Lett 6: 473-476 (1996) Article DOI: 10.1016/0960-894X(96)00053-4 BindingDB Entry DOI: 10.7270/Q2GQ6XQ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50073754 ((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human dihydrofolate reductase (DHFR) | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50073752 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human dihydrofolate reductase (DHFR) | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50073753 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human dihydrofolate reductase (DHFR) | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 2 subtypes expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 40.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 2 subtypes expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 74.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50202407 ((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 93.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167033 ((1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 146 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50202407 ((-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 149 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]LY341495 from human recombinant mGluR2 in RGT cells | J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells. | J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 409 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 409 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167034 ((1S,2S,4S,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 511 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167034 ((1S,2S,4S,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 635 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50073753 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167033 ((1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 983 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50073754 ((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human Thymidylate synthase | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50288820 ((S)-2-{(S)-4-[4-(2,4-Diamino-pyrimidin-5-yl)-butyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against Recombinant human thymidylate synthase (TS). | Bioorg Med Chem Lett 6: 473-476 (1996) Article DOI: 10.1016/0960-894X(96)00053-4 BindingDB Entry DOI: 10.7270/Q2GQ6XQ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50288821 ((S)-2-{(S)-4-[3-(2,4-Diamino-pyrimidin-5-yl)-propy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against Recombinant human thymidylate synthase (TS) | Bioorg Med Chem Lett 6: 473-476 (1996) Article DOI: 10.1016/0960-894X(96)00053-4 BindingDB Entry DOI: 10.7270/Q2GQ6XQ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50073753 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human Thymidylate synthase enzyme | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50073752 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against recombinant human Thymidylate synthase enzyme | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50073752 ((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50073754 ((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme | Bioorg Med Chem Lett 9: 75-8 (1999) BindingDB Entry DOI: 10.7270/Q2SX6CCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167031 ((1R,2R,4S,5S,6R)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 2 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167031 ((1R,2R,4S,5S,6R)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3 | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50167033 ((1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu2 receptor | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptor | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167032 ((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptor | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50167033 ((1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptor | J Med Chem 48: 3605-12 (2005) Article DOI: 10.1021/jm040222y BindingDB Entry DOI: 10.7270/Q2NS0TDR | |||||||||||
More data for this Ligand-Target Pair |
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