Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50073752 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_54286 |
---|
Ki | 0.690000±n/a nM |
---|
Citation | Gossett, LS; Habeck, LL; Shackelford, KA; Mendelsohn, LG; Gates, SB; Worzalla, JF; Self, TD; Theobald, KS; Andis, SL; Schultz, RM; Shih, C The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents. Bioorg Med Chem Lett9:75-8 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
BDBM50073752 |
---|
n/a |
---|
Name | BDBM50073752 |
Synonyms: | (R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-thiophene-2-carbonyl}-amino)-2-methyl-pentanedioic acid | CHEMBL168069 | LY-335580 |
Type | Small organic molecule |
Emp. Form. | C20H26N6O5S |
Mol. Mass. | 462.523 |
SMILES | C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)s1)C(O)=O |
Structure |
|