| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50203313 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_425257 (CHEMBL856833) |
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| IC50 | >25000±n/a nM |
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| Citation |  Liverton, NJ; Bednar, RA; Bednar, B; Butcher, JW; Claiborne, CF; Claremon, DA; Cunningham, M; DiLella, AG; Gaul, SL; Libby, BE; Lyle, EA; Lynch, JJ; McCauley, JA; Mosser, SD; Nguyen, KT; Stump, GL; Sun, H; Wang, H; Yergey, J; Koblan, KS Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist. J Med Chem50:807-19 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50203313 |
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| n/a |
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| Name | BDBM50203313 |
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| Synonyms: | CHEMBL218017 | benzyl 4-[(pyridin-2-ylamino)methyl]piperidine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N3O2 |
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| Mol. Mass. | 325.4048 |
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| SMILES | O=C(OCc1ccccc1)N1CCC(CNc2ccccn2)CC1 |
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| Structure | 
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