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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203587 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 6.4±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50203587 | |||
| n/a | |||
| Name | BDBM50203587 | ||
| Synonyms: | CHEMBL392655 | [8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-ethyl-phenethyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H30ClN5 | ||
| Mol. Mass. | 472.024 | ||
| SMILES | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 |(16.66,-44.12,;18.18,-43.85,;19.17,-45.03,;20.68,-44.76,;21.21,-43.31,;20.22,-42.13,;20.74,-40.69,;19.75,-39.51,;18.24,-39.78,;17.71,-41.24,;18.71,-42.41,;18.65,-46.48,;19.64,-47.66,;19.27,-49.15,;17.84,-49.73,;20.57,-49.96,;21.75,-48.98,;23.29,-48.87,;24.28,-50.05,;25.79,-49.78,;26.31,-48.33,;26.78,-50.95,;26.25,-52.41,;27.24,-53.59,;24.73,-52.67,;23.75,-51.49,;22.23,-51.76,;23.67,-47.38,;25.03,-46.66,;25.09,-45.11,;23.77,-44.29,;22.41,-45.01,;22.35,-46.55,;21.17,-47.55,)| | ||
| Structure | 
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