Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203616 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 700±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50203616 | |||
| n/a | |||
| Name | BDBM50203616 | ||
| Synonyms: | 8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-(3-phenethyl-pyrrolidin-1-ylmethyl)-8H-1,3a,7,8-tetraaza-cyclopenta[a]indene | CHEMBL248163 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H32ClN5 | ||
| Mol. Mass. | 498.062 | ||
| SMILES | Cc1nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n2c1CN1CCC(CCc2ccccc2)C1 |w:26.30,(7.31,-23,;8.74,-22.42,;10.04,-23.23,;11.22,-22.24,;12.76,-22.13,;13.75,-23.32,;15.26,-23.05,;15.78,-21.6,;16.25,-24.22,;15.72,-25.68,;16.71,-26.85,;14.2,-25.94,;13.22,-24.76,;11.7,-25.02,;13.14,-20.65,;14.5,-19.92,;14.56,-18.38,;13.19,-17.49,;11.88,-18.28,;11.82,-19.82,;10.64,-20.81,;9.11,-20.92,;8.11,-19.75,;8.64,-18.3,;10.11,-17.88,;10.16,-16.34,;8.72,-15.81,;8.29,-14.33,;6.79,-13.96,;6.36,-12.49,;7.43,-11.38,;7.01,-9.9,;5.51,-9.53,;4.44,-10.65,;4.87,-12.12,;7.77,-17.03,)| | ||
| Structure | 
| ||