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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203623 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 2900±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50203623 | |||
| n/a | |||
| Name | BDBM50203623 | ||
| Synonyms: | CHEMBL396822 | [8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-(1-methyl-butyl)-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H28ClN5 | ||
| Mol. Mass. | 409.955 | ||
| SMILES | CCCC(C)NCc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 |w:3.3,(-7.02,-13.67,;-5.56,-14.16,;-5.25,-15.67,;-3.8,-16.16,;-2.64,-15.14,;-3.49,-17.67,;-4.3,-18.98,;-3.57,-20.34,;-4.24,-21.73,;-5.76,-22,;-3.14,-22.79,;-1.78,-22.07,;-.25,-22.29,;.47,-23.65,;2,-23.7,;2.81,-22.39,;2.73,-25.05,;1.91,-26.36,;2.63,-27.72,;.37,-26.31,;-.35,-24.95,;-1.89,-24.89,;.43,-20.91,;1.91,-20.49,;2.29,-18.98,;1.13,-17.83,;-.31,-18.33,;-.68,-19.83,;-2.05,-20.55,)| | ||
| Structure | 
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