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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203625 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 7.8±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50203625 | |||
| n/a | |||
| Name | BDBM50203625 | ||
| Synonyms: | CHEMBL246501 | ethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-phenethyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33N5 | ||
| Mol. Mass. | 451.6058 | ||
| SMILES | CCN(CCc1ccccc1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ncccc3n12 |(38.71,1.01,;38.18,-.44,;36.66,-.71,;35.88,.62,;34.34,.6,;33.55,1.92,;34.31,3.25,;33.52,4.58,;31.98,4.56,;31.23,3.2,;32.02,1.89,;36.14,-2.15,;37.13,-3.33,;36.76,-4.83,;35.34,-5.41,;38.07,-5.64,;39.25,-4.65,;40.79,-4.54,;41.78,-5.72,;43.28,-5.45,;43.81,-4.01,;44.27,-6.63,;43.75,-8.08,;44.74,-9.26,;42.23,-8.35,;41.24,-7.17,;39.73,-7.43,;41.16,-3.06,;42.53,-2.33,;42.59,-.78,;41.27,.04,;39.91,-.69,;39.85,-2.23,;38.67,-3.22,)| | ||
| Structure | 
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