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TargetKiSS-1 receptor
LigandBDBM50203805
Substrate/Competitorn/a
Meas. Tech.ChEMBL_425686 (CHEMBL912002)
Ki 551.8±n/a nM
Citation Orsini, MJ; Klein, MA; Beavers, MP; Connolly, PJ; Middleton, SA; Mayo, KH Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening. J Med Chem50:462-71 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
KiSS-1 receptor
Name:KiSS-1 receptor
Synonyms:AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42613.79
Organism:Homo sapiens (Human)
Description:Binding assay was performed using membranes from the CHO cell transfectants.
Residue:398
Sequence:
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50203805
n/a
NameBDBM50203805
Synonyms:CHEMBL220853 | LPNYNWNSFGLRF
TypeSmall organic molecule
Emp. Form.C78H106N20O19
Mol. Mass.1627.7988
SMILESCC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:58.61,4.4,72.75,87.91,36.37,12.13,106.110,wD:66.69,24.24,95.99,16.16,44.45,(-15.98,-18.31,;-15.96,-19.85,;-17.29,-20.63,;-14.62,-20.59,;-14.61,-22.15,;-15.94,-22.92,;-13.27,-22.92,;-13.27,-24.46,;-11.94,-22.16,;-11.46,-20.7,;-9.92,-20.7,;-9.44,-22.15,;-10.69,-23.07,;-10.69,-24.61,;-12.03,-25.37,;-9.36,-25.38,;-9.36,-26.92,;-10.7,-27.69,;-10.7,-29.23,;-9.37,-30,;-12.04,-29.99,;-8.04,-27.69,;-8.04,-29.23,;-6.7,-26.92,;-5.37,-27.69,;-5.37,-29.23,;-4.03,-30,;-4.04,-31.54,;-2.71,-32.31,;-1.37,-31.54,;-.04,-32.31,;-1.37,-29.99,;-2.7,-29.24,;-4.03,-26.92,;-4.03,-25.38,;-2.7,-27.7,;-1.37,-26.93,;-1.36,-25.39,;-.03,-24.62,;1.3,-25.39,;-.02,-23.08,;-.03,-27.7,;-.03,-29.24,;1.3,-26.93,;2.64,-27.7,;2.64,-29.24,;3.96,-30.01,;5.22,-29.02,;6.45,-30.01,;5.98,-31.48,;6.74,-32.79,;5.98,-34.12,;4.44,-34.12,;3.68,-32.79,;4.45,-31.47,;3.97,-26.93,;3.97,-25.39,;5.31,-27.7,;6.64,-26.94,;6.64,-25.4,;7.97,-24.63,;9.31,-25.4,;7.97,-23.09,;7.97,-27.71,;7.97,-29.25,;9.31,-26.94,;10.64,-27.71,;10.64,-29.25,;11.97,-30.02,;11.98,-26.94,;11.98,-25.4,;13.31,-27.71,;14.64,-26.95,;14.64,-25.41,;15.98,-24.64,;17.31,-25.41,;18.65,-24.64,;18.65,-23.1,;17.3,-22.33,;15.98,-23.1,;15.98,-27.72,;15.97,-29.26,;17.31,-26.95,;18.65,-27.71,;19.98,-26.94,;19.98,-25.4,;21.31,-27.71,;22.64,-26.95,;22.65,-25.41,;23.98,-24.64,;23.98,-23.1,;25.32,-25.41,;23.97,-27.72,;23.97,-29.26,;25.31,-26.95,;26.64,-27.72,;26.64,-29.26,;27.98,-30.03,;27.98,-31.57,;29.31,-32.34,;29.3,-33.88,;30.63,-34.66,;27.97,-34.65,;27.98,-26.95,;27.98,-25.41,;29.31,-27.72,;30.64,-26.96,;30.64,-25.42,;31.98,-24.65,;33.31,-25.43,;34.65,-24.66,;34.65,-23.12,;33.3,-22.35,;31.98,-23.12,;31.98,-27.73,;33.31,-26.96,;31.98,-29.27,)|
Structure
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