| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
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| Ligand | BDBM50206423 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_428524 (CHEMBL919881) |
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| IC50 | 3500±n/a nM |
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| Citation |  Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S From five- to six-membered rings: 3,4-diarylquinolinone as lead for novel p38MAP kinase inhibitors. J Med Chem50:1213-21 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 10 |
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| Name: | Mitogen-activated protein kinase 10 |
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| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52586.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 464 |
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| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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| BDBM50206423 |
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| n/a |
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| Name | BDBM50206423 |
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| Synonyms: | 4-(5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl)pyridine | 4-[5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl]pyridine | 5-(4-fluorophenyl)-3-isopropyl-4-(pyridin-4-yl)isoxazole | CHEMBL375428 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15FN2O |
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| Mol. Mass. | 282.3122 |
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| SMILES | CC(C)c1noc(c1-c1ccncc1)-c1ccc(F)cc1 |
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| Structure | 
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