| Reaction Details |
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 | Report a problem with these data |
| Target | M1 family aminopeptidase |
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| Ligand | BDBM50197505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_428661 (CHEMBL915808) |
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| IC50 | 225±n/a nM |
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| Citation |  Flipo, M; Beghyn, T; Leroux, V; Florent, I; Deprez, BP; Deprez-Poulain, RF Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem50:1322-34 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| M1 family aminopeptidase |
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| Name: | M1 family aminopeptidase |
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| Synonyms: | AMPN_PLAF7 | M1AAP | Zinc aminopeptidase | m1-family aminopeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126072.31 |
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| Organism: | Plasmodium falciparum (isolate FcB1 / Columbia) |
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| Description: | ChEMBL_735637 |
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| Residue: | 1085 |
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| Sequence: | MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKN
YNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNN
NGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNV
ENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNV
GEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPET
NYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKV
NEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVS
KLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKK
NSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTR
LSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYK
KGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNY
DAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFV
FNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNY
NEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNL
DTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNT
LLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLL
QEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKL
IAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLR
LTNKL
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| BDBM50197505 |
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| n/a |
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| Name | BDBM50197505 |
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| Synonyms: | 2-(3-phenoxybenzyl)-N1-hydroxy-N3-(4-phenylbutyl)malonamide | CHEMBL376199 | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-phenyl-butyl)-malonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N2O4 |
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| Mol. Mass. | 432.5115 |
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| SMILES | ONC(=O)C(Cc1cccc(Oc2ccccc2)c1)C(=O)NCCCCc1ccccc1 |
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| Structure | 
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