Reaction Details |
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Target | Phospholipase A2, membrane associated |
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Ligand | BDBM50206910 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_428854 (CHEMBL917130) |
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IC50 | 1150±n/a nM |
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Citation | Touaibia, M; Djimdé, A; Cao, F; Boilard, E; Bezzine, S; Lambeau, G; Redeuilh, C; Lamouri, A; Massicot, F; Chau, F; Dong, CZ; Heymans, F Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem50:1618-26 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phospholipase A2, membrane associated |
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Name: | Phospholipase A2, membrane associated |
Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
Type: | Hydrolase |
Mol. Mass.: | 16101.20 |
Organism: | Homo sapiens (Human) |
Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
Residue: | 144 |
Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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BDBM50206910 |
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n/a |
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Name | BDBM50206910 |
Synonyms: | (+/-)-1-O-(4-cyanomethylphenyl)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)methylphenyl]-2-O-octadecylglycerol | CHEMBL223880 |
Type | Small organic molecule |
Emp. Form. | C38H55N3O5 |
Mol. Mass. | 633.8604 |
SMILES | CCCCCCCCCCCCCCCCCCOC(COCc1ccc(cc1)C#N)COc1ccc(Cc2nc(=O)o[nH]2)cc1 |
Structure |
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