| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50207795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454897 (CHEMBL886926) |
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| IC50 | 481±n/a nM |
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| Citation |  Webster, SP; Ward, P; Binnie, M; Craigie, E; McConnell, KM; Sooy, K; Vinter, A; Seckl, JR; Walker, BR Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett17:2838-43 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32369.70 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P50172 |
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| Residue: | 292 |
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| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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| BDBM50207795 |
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| n/a |
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| Name | BDBM50207795 |
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| Synonyms: | CHEMBL246952 | adamantan-1-yl-(3,4-dihydro-2H-quinolin-1-yl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25NO |
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| Mol. Mass. | 295.4186 |
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| SMILES | O=C(N1CCCc2ccccc12)C12CC3CC(CC(C3)C1)C2 |TLB:15:16:13.14.19:20,THB:15:14:20:21.16.17,17:16:13:19.18.20,17:18:13:21.15.16| |
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| Structure | 
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