| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-2 |
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| Ligand | BDBM50208065 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_429275 (CHEMBL915382) |
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| IC50 | >100000±n/a nM |
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| Citation |  Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem50:1610-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-2 |
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| Name: | Glycine receptor subunit alpha-2 |
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| Synonyms: | GLRA2 | GLRA2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52016.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_429275 |
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| Residue: | 452 |
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| Sequence: | MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFP
MDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGK
FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQ
SSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNK
EEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT
ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
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| BDBM50208065 |
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| n/a |
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| Name | BDBM50208065 |
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| Synonyms: | CHEMBL221355 | methyl 2-[(1R,6R,8S,11S,14E)-8-tert-butyl-6-hydroxy-5,15-dioxo-2,4,16-trioxapentacyclo[8.4.2.0^{1,11}.0^{3,7}.0^{7,11}]hexadecan-14-ylidene]propanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O8 |
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| Mol. Mass. | 406.4263 |
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| SMILES | COC(=O)C(\C)=C1/CC[C@@]23C4C[C@@H](C(C)(C)C)C22[C@@H](O)C(=O)OC2O[C@]13C(=O)O4 |
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| Structure | 
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