| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-2 |
|---|
| Ligand | BDBM50208090 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_429275 (CHEMBL915382) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem50:1610-7 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycine receptor subunit alpha-2 |
|---|
| Name: | Glycine receptor subunit alpha-2 |
|---|
| Synonyms: | GLRA2 | GLRA2_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52016.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_429275 |
|---|
| Residue: | 452 |
|---|
| Sequence: | MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFP
MDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGK
FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQ
SSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNK
EEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT
ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
|
|
|
|---|
| BDBM50208090 |
|---|
| n/a |
|---|
| Name | BDBM50208090 |
|---|
| Synonyms: | (1S,8S,11S,13S,16S,17R)-8-tert-butyl-17-hydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,6,15,18-tetrone | CHEMBL376302 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22O9 |
|---|
| Mol. Mass. | 406.3833 |
|---|
| SMILES | C[C@@H]1C(=O)O[C@H]2C[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)C3=O)O[C@]4(C(=O)O5)[C@@]12O |
|---|
| Structure | 
|
|---|
Search and Browse
