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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | B1 bradykinin receptor | ||
| Ligand | BDBM50210371 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_443978 (CHEMBL893140) | ||
| Ki | 3.7±n/a nM | ||
| Citation |  Su, DS; Lim, JL; Markowitz, MK; Wan, BL; Murphy, KL; Reiss, DR; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RS; Pettibone, DJ; Tang, C; Prueksaritanont, T; Freidinger, RM; Bock, MG Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes. Bioorg Med Chem Lett17:3006-9 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| B1 bradykinin receptor | |||
| Name: | B1 bradykinin receptor | ||
| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 40508.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P46663 | ||
| Residue: | 353 | ||
| Sequence: |
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| BDBM50210371 | |||
| n/a | |||
| Name | BDBM50210371 | ||
| Synonyms: | CHEMBL388030 | N-(2-((4-cyano-4-(3-fluorophenyl)cyclohexyl)methylamino)pyridin-3-yl)-3,3,3-trifluoropropanamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22F4N4O | ||
| Mol. Mass. | 434.4299 | ||
| SMILES | Fc1cccc(c1)C1(CCC(CNc2ncccc2NC(=O)CC(F)(F)F)CC1)C#N |(20.86,-36.92,;21.64,-35.6,;23.18,-35.6,;23.96,-34.29,;23.2,-32.94,;21.66,-32.93,;20.87,-34.25,;20.9,-31.59,;19.54,-32.41,;18.22,-31.64,;18.21,-30.09,;16.86,-29.33,;15.53,-30.11,;14.2,-30.89,;14.2,-32.44,;12.87,-33.21,;11.53,-32.44,;11.53,-30.89,;12.88,-30.12,;12.87,-28.58,;11.54,-27.8,;10.21,-28.57,;11.54,-26.26,;10.21,-25.49,;8.87,-24.72,;10.98,-24.16,;9.44,-26.83,;19.53,-29.3,;20.88,-30.06,;22.27,-30.89,;23.63,-30.18,)| | ||
| Structure | 
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