Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50211330

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_444279 (CHEMBL894519)

259±n/a nM

Citation

Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM50211330

n/a

Name

BDBM50211330

Synonyms:

5-chloro-N-((1s,4s)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-2-methoxybenzenesulfonamide | CHEMBL233816

Type

Small organic molecule

Emp. Form.

C26H36ClN3O4S

Mol. Mass.

522.1

SMILES

COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCN(CC1)c1ccccc1OC(C)C |wU:16.20,13.13,(7.58,-42.99,;8.35,-41.66,;7.58,-40.32,;8.35,-38.99,;7.58,-37.66,;6.04,-37.66,;5.27,-36.32,;5.27,-38.99,;6.04,-40.32,;5.27,-41.66,;3.94,-40.89,;6.6,-42.43,;4.5,-42.99,;2.96,-42.99,;2.19,-44.32,;.65,-44.32,;-.12,-42.99,;.65,-41.66,;2.19,-41.66,;-1.66,-42.99,;-2.44,-44.32,;-3.98,-44.32,;-4.75,-42.99,;-3.98,-41.66,;-2.44,-41.66,;-6.29,-42.99,;-7.06,-44.32,;-8.6,-44.32,;-9.37,-42.99,;-8.6,-41.66,;-7.06,-41.66,;-6.29,-40.32,;-7.06,-38.99,;-6.29,-37.66,;-8.6,-38.99,)|

Structure