| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
|---|
| Ligand | BDBM50211452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_455596 (CHEMBL886376) |
|---|
| Ki | 11±n/a nM |
|---|
| Citation |  Chao, J; Taveras, AG; Chao, J; Aki, C; Dwyer, M; Yu, Y; Purakkattle, B; Rindgen, D; Jakway, J; Hipkin, W; Fosetta, J; Fan, X; Lundell, D; Fine, J; Minnicozzi, M; Phillips, J; Merritt, JR C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists. Bioorg Med Chem Lett17:3778-83 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-X-C chemokine receptor type 1 |
|---|
| Name: | C-X-C chemokine receptor type 1 |
|---|
| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39803.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25024 |
|---|
| Residue: | 350 |
|---|
| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
|
|
|
|---|
| BDBM50211452 |
|---|
| n/a |
|---|
| Name | BDBM50211452 |
|---|
| Synonyms: | (R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)-2-methylpropylamino)-3,4-dioxocyclobut-1-enylamino)-N,N-dimethylbenzamide | CHEMBL247149 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29N3O5 |
|---|
| Mol. Mass. | 439.5042 |
|---|
| SMILES | CC(C)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
