| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50212129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_438766 (CHEMBL889103) |
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| IC50 | 147±n/a nM |
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| Citation |  Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L 3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2. Bioorg Med Chem Lett17:3636-41 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | CCR2_MOUSE | Ccr2 | Cmkbr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42795.68 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502265 |
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| Residue: | 373 |
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| Sequence: | MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPP
LYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWV
FGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVV
AVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILH
TLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAM
QVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTF
TPSTGEQEVSVGL
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| BDBM50212129 |
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| n/a |
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| Name | BDBM50212129 |
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| Synonyms: | 1-(cyclobutylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide | CHEMBL231142 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38F4N2O |
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| Mol. Mass. | 554.6612 |
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| SMILES | C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CCC2)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F |w:15.17,18.21,c:8| |
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| Structure | 
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